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Urokinase Plasminogen Activator Induces Pro-Fibrotic/M2 Phenotype in Murine Cardiac Macrophages

OBJECTIVE: Inflammation and fibrosis are intertwined in multiple disease processes. We have previously found that over-expression of urokinase plasminogen activator in macrophages induces spontaneous macrophage accumulation and fibrosis specific to the heart in mice. Understanding the relationship b...

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Detalhes bibliográficos
Main Authors: Meznarich, Jessica, Malchodi, Laura, Helterline, Deri, Ramsey, Stephen A., Bertko, Kate, Plummer, Tabitha, Plawman, Abigail, Gold, Elizabeth, Stempien-Otero, April
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594198/
https://ncbi.nlm.nih.gov/pubmed/23536772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057837
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