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Mutational analysis of vaccinia virus mRNA cap (guanine-N7) methyltransferase reveals essential contributions of the N-terminal peptide that closes over the active site
RNA guanine-N7 methyltransferase catalyzes the third step of eukaryal mRNA capping, the transfer of a methyl group from AdoMet to GpppRNA to form m(7)GpppRNA. Mutational and crystallographic analyses of cellular and poxvirus cap methyltransferases have yielded a coherent picture of a conserved activ...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2008
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2578867/ https://ncbi.nlm.nih.gov/pubmed/18799596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1201308 |
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