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Sinefungin resistance of Saccharomyces cerevisiae arising from sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase
The S-adenosylmethionine (AdoMet) analog sinefungin is a natural product antibiotic that inhibits nucleic acid methyltransferases and arrests the growth of unicellular eukarya and eukaryal viruses. The basis for the particular sensitivity of fungi and protozoa to sinefungin is not known. Here we rep...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2175321/ https://ncbi.nlm.nih.gov/pubmed/17932050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm817 |
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