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Cap analog substrates reveal three clades of cap guanine-N2 methyltransferases with distinct methyl acceptor specificities
The Tgs proteins are structurally homologous AdoMet-dependent eukaryal enzymes that methylate the N2 atom of 7-methyl guanosine nucleotides. They have an imputed role in the synthesis of the 2,2,7-trimethylguanosine (TMG) RNA cap. Here we exploit a collection of cap-like substrates to probe the repe...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802030/ https://ncbi.nlm.nih.gov/pubmed/19926722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1872110 |
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