Cap analog substrates reveal three clades of cap guanine-N2 methyltransferases with distinct methyl acceptor specificities

The Tgs proteins are structurally homologous AdoMet-dependent eukaryal enzymes that methylate the N2 atom of 7-methyl guanosine nucleotides. They have an imputed role in the synthesis of the 2,2,7-trimethylguanosine (TMG) RNA cap. Here we exploit a collection of cap-like substrates to probe the repe...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Benarroch, Delphine, Jankowska-Anyszka, Marzena, Stepinski, Janusz, Darzynkiewicz, Edward, Shuman, Stewart
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802030/
https://ncbi.nlm.nih.gov/pubmed/19926722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1872110
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