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Efficient Catalytic Turnover of Cytochrome P450(cam) is Supported by a T252N Mutation

A Thr (or Ser) residue on the I-helix is a highly conserved structural feature of cytochrome P450 enzymes. It is believed to be indispensable as a proton delivery shuttle in the oxygen activation process. Previous work showed that P450(cin) (CYP176A1), which contains an Asn instead of the conserved...

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Hlavní autoři: Kim, Donghak, Heo, Yong-Seok, Ortiz de Montellano, Paul R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577879/
https://ncbi.nlm.nih.gov/pubmed/18359283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.02.044
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