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Efficient Catalytic Turnover of Cytochrome P450(cam) is Supported by a T252N Mutation
A Thr (or Ser) residue on the I-helix is a highly conserved structural feature of cytochrome P450 enzymes. It is believed to be indispensable as a proton delivery shuttle in the oxygen activation process. Previous work showed that P450(cin) (CYP176A1), which contains an Asn instead of the conserved...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577879/ https://ncbi.nlm.nih.gov/pubmed/18359283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.02.044 |
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