OTT-MAL Is a Deregulated Activator of Serum Response Factor-Dependent Gene Expression

The OTT-MAL/RBM15-MKL1 fusion protein is the result of the recurrent translocation t(1;22) in acute megakaryocytic leukemia in infants. How it contributes to the malignancy is unknown. The 3′ fusion partner, MAL/MKL1/MRTF-A, is a transcriptional coactivator of serum response factor (SRF). MAL plays...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Descot, Arnaud, Rex-Haffner, Monika, Courtois, Geneviève, Bluteau, Dominique, Menssen, Antje, Mercher, Thomas, Bernard, Olivier A., Treisman, Richard, Posern, Guido
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577437/
https://ncbi.nlm.nih.gov/pubmed/18710951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00303-08
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi