The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model

Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) associated with a poor prognosis. The genetics and pathophysiology of AMKL are not well understood. We generated a knockin mouse model of the one twenty-two–megakaryocytic acute leukemia (OTT-MAL) fusion oncogene that r...

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Detalhes bibliográficos
Main Authors: Mercher, Thomas, Raffel, Glen D., Moore, Sandra A., Cornejo, Melanie G., Baudry-Bluteau, Dominique, Cagnard, Nicolas, Jesneck, Jonathan L., Pikman, Yana, Cullen, Dana, Williams, Ifor R., Akashi, Koichi, Shigematsu, Hirokazu, Bourquin, Jean-Pierre, Giovannini, Marco, Vainchenker, William, Levine, Ross L., Lee, Benjamin H., Bernard, Olivier A., Gilliland, D. Gary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662544/
https://ncbi.nlm.nih.gov/pubmed/19287095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35901
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