OTT-MAL Is a Deregulated Activator of Serum Response Factor-Dependent Gene Expression

The OTT-MAL/RBM15-MKL1 fusion protein is the result of the recurrent translocation t(1;22) in acute megakaryocytic leukemia in infants. How it contributes to the malignancy is unknown. The 3′ fusion partner, MAL/MKL1/MRTF-A, is a transcriptional coactivator of serum response factor (SRF). MAL plays...

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Main Authors: Descot, Arnaud, Rex-Haffner, Monika, Courtois, Geneviève, Bluteau, Dominique, Menssen, Antje, Mercher, Thomas, Bernard, Olivier A., Treisman, Richard, Posern, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577437/
https://ncbi.nlm.nih.gov/pubmed/18710951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00303-08
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