Hypoxia-Inducible Factor (HIF)-2 regulates Vascular Tumorigenesis in Mice

The von Hippel-Lindau tumor suppressor pVHL regulates the stability of Hypoxia-Inducible Factors (HIF) -1 and –2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor (VEGF). Loss of...

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Bibliografiske detaljer
Main Authors: Rankin, Erinn B., Rha, Jennifer, Unger, Travis L., Wu, Chia H., Shutt, Heather P., Johnson, Randall S., Simon, M. Celeste, Keith, Brian, Haase, Volker H.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575082/
https://ncbi.nlm.nih.gov/pubmed/18490920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.160
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