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Hypoxia-Inducible Factor (HIF)-2 regulates Vascular Tumorigenesis in Mice
The von Hippel-Lindau tumor suppressor pVHL regulates the stability of Hypoxia-Inducible Factors (HIF) -1 and –2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor (VEGF). Loss of...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2575082/ https://ncbi.nlm.nih.gov/pubmed/18490920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.160 |
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