Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

The kidney is the main physiologic source of erythropoietin (EPO) in the adult and responds to decreases in tissue oxygenation with increased EPO production. Although studies in mice with liver-specific or global gene inactivation have shown that hypoxia-inducible factor 2 (Hif-2) plays a major role...

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Detalhes bibliográficos
Main Authors: Kapitsinou, Pinelopi P., Liu, Qingdu, Unger, Travis L., Rha, Jennifer, Davidoff, Olena, Keith, Brian, Epstein, Jonathan A., Moores, Sheri L., Erickson-Miller, Connie L., Haase, Volker H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974609/
https://ncbi.nlm.nih.gov/pubmed/20628150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270322
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