Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

The kidney is the main physiologic source of erythropoietin (EPO) in the adult and responds to decreases in tissue oxygenation with increased EPO production. Although studies in mice with liver-specific or global gene inactivation have shown that hypoxia-inducible factor 2 (Hif-2) plays a major role...

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Main Authors: Kapitsinou, Pinelopi P., Liu, Qingdu, Unger, Travis L., Rha, Jennifer, Davidoff, Olena, Keith, Brian, Epstein, Jonathan A., Moores, Sheri L., Erickson-Miller, Connie L., Haase, Volker H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974609/
https://ncbi.nlm.nih.gov/pubmed/20628150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270322
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