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Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

The kidney is the main physiologic source of erythropoietin (EPO) in the adult and responds to decreases in tissue oxygenation with increased EPO production. Although studies in mice with liver-specific or global gene inactivation have shown that hypoxia-inducible factor 2 (Hif-2) plays a major role...

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Hlavní autoři: Kapitsinou, Pinelopi P., Liu, Qingdu, Unger, Travis L., Rha, Jennifer, Davidoff, Olena, Keith, Brian, Epstein, Jonathan A., Moores, Sheri L., Erickson-Miller, Connie L., Haase, Volker H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974609/
https://ncbi.nlm.nih.gov/pubmed/20628150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270322
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