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Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury

Acute kidney injury (AKI) due to ischemia is an important contributor to the progression of chronic kidney disease (CKD). Key mediators of cellular adaptation to hypoxia are oxygen-sensitive hypoxia-inducible factors (HIF), which are regulated by prolyl-4-hydroxylase domain (PHD)-containing dioxygen...

詳細記述

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書誌詳細
主要な著者: Kapitsinou, Pinelopi P., Jaffe, Jonathan, Michael, Mark, Swan, Christina E., Duffy, Kevin J., Erickson-Miller, Connie L., Haase, Volker H.
フォーマット: Artigo
言語:Inglês
出版事項: American Physiological Society 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362175/
https://ncbi.nlm.nih.gov/pubmed/22262480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00667.2011
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