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Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury

Acute kidney injury (AKI) due to ischemia is an important contributor to the progression of chronic kidney disease (CKD). Key mediators of cellular adaptation to hypoxia are oxygen-sensitive hypoxia-inducible factors (HIF), which are regulated by prolyl-4-hydroxylase domain (PHD)-containing dioxygen...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kapitsinou, Pinelopi P., Jaffe, Jonathan, Michael, Mark, Swan, Christina E., Duffy, Kevin J., Erickson-Miller, Connie L., Haase, Volker H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362175/
https://ncbi.nlm.nih.gov/pubmed/22262480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00667.2011
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