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Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury
Acute kidney injury (AKI) due to ischemia is an important contributor to the progression of chronic kidney disease (CKD). Key mediators of cellular adaptation to hypoxia are oxygen-sensitive hypoxia-inducible factors (HIF), which are regulated by prolyl-4-hydroxylase domain (PHD)-containing dioxygen...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362175/ https://ncbi.nlm.nih.gov/pubmed/22262480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00667.2011 |
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