Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury

Acute kidney injury (AKI) due to ischemia is an important contributor to the progression of chronic kidney disease (CKD). Key mediators of cellular adaptation to hypoxia are oxygen-sensitive hypoxia-inducible factors (HIF), which are regulated by prolyl-4-hydroxylase domain (PHD)-containing dioxygen...

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Bibliographic Details
Main Authors: Kapitsinou, Pinelopi P., Jaffe, Jonathan, Michael, Mark, Swan, Christina E., Duffy, Kevin J., Erickson-Miller, Connie L., Haase, Volker H.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362175/
https://ncbi.nlm.nih.gov/pubmed/22262480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00667.2011
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