Overcoming S-Phase Checkpoint-Mediated Resistance: Sequence-Dependent Synergy of Gemcitabine and SN-38 In Human Carcinoma Cell Lines

Although agents that inhibit DNA synthesis are widely used in the treatment of cancer, the optimal method for combining such agents and the mechanism of their synergy is poorly understood. The present study examined the effects of combining gemcitabine and SN-38 (the active metabolite of irinotecan)...

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Hauptverfasser: Gálvez-Peralta, Marina, Dai, Nga T., Loegering, David A., Flatten, Karen, Safgren, Stephanie, Wagner, Jill, Ames, Matthew M., Karnitz, Larry M., Kaufmann, Scott H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574763/
https://ncbi.nlm.nih.gov/pubmed/18509065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.047787
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