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The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1
DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires the independent chromatin loading of the ATRIP–ATR (ATR-interacting protein/ATM [ataxia-telangiectasia mutated]–Rad3-related kinase) complex and the Rad9–Hus1–Rad1 (9–1–1) clamp. We show that Rad9...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1891424/ https://ncbi.nlm.nih.gov/pubmed/17575048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1547007 |
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