The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1

DNA replication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires the independent chromatin loading of the ATRIP–ATR (ATR-interacting protein/ATM [ataxia-telangiectasia mutated]–Rad3-related kinase) complex and the Rad9–Hus1–Rad1 (9–1–1) clamp. We show that Rad9...

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Main Authors: Delacroix, Sinny, Wagner, Jill M., Kobayashi, Masahiko, Yamamoto, Ken-ichi, Karnitz, Larry M.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891424/
https://ncbi.nlm.nih.gov/pubmed/17575048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1547007
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