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Quantification of Ligand-Regulated Nuclear Receptor Corepressor and Coactivator Binding, Key Interactions Determining Ligand Potency and Efficacy for Thyroid Hormone Receptor

The potency and efficacy of ligands for nuclear receptors (NR) result both from the affinity of the ligand for the receptor and the affinity that various coregulatory proteins have for ligand-receptor complexes; the latter interaction, however, is rarely quantified. To understand the molecular basis...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Jeyakumar, M., Webb, Paul, Baxter, John D., Scanlan, Thomas S., Katzenellenbogen, John A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574600/
https://ncbi.nlm.nih.gov/pubmed/18558711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800393u
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