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Arylstibonic Acids: Novel Inhibitors and Activators of Human Topoisomerase IB
Human topoisomerase IB (hTopo) forms a covalent phosphotyrosyl linkage with the DNA backbone, and controls genomic DNA topology by relaxing DNA supercoils during the processes of DNA replication, transcription, chromosome condensation and decondensation. The essential role of hTopo in these processe...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574574/ https://ncbi.nlm.nih.gov/pubmed/18508107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2008.04.001 |
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