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Diverse Energetic Effects of Charge Reversal Mutations of Poxvirus Topoisomerase IB
A key aspect of the reaction mechanism of type IB topoisomerases is the controlled unwinding of DNA supercoils while the enzyme is transiently bound to one strand of the DNA duplex via a phosphotyrosyl linkage. In this complex, the mobile segment of the bound DNA downstream from the site of cleavage...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319507/ https://ncbi.nlm.nih.gov/pubmed/22417571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3001903 |
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