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POTENT INHIBITION OF HUMAN AP ENDONUCLEASE 1 BY ARYLSTIBONIC ACIDS

Human apurinic/apyrimidinic endonuclease (Ape1) plays an important role by processing the >10,000 highly toxic abasic sites generated in the genome of each cell every day. Ape1 has recently emerged as a target for inhibition as its overexpression in tumors has been linked with poor response to bo...

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Detalhes bibliográficos
Main Authors: Seiple, Lauren A., Cardellina, John H., Akee, Rhone, Stivers, James T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720577/
https://ncbi.nlm.nih.gov/pubmed/18042731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.042622
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