An Alphavirus Replicon-Based Human Metapneumovirus Vaccine Is Immunogenic and Protective in Mice and Cotton Rats

Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that causes upper and lower respiratory tract infections in infants, the elderly, and immunocompromised individuals worldwide. Here, we developed Venezuelan equine encephalitis virus replicon particles (VRPs) encoding hMPV fusion (F...

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Autors principals: Mok, Hoyin, Tollefson, Sharon J., Podsiad, Amy B., Shepherd, Bryan E., Polosukhin, Vasiliy V., Johnston, Robert E., Williams, John V., Crowe, James E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573258/
https://ncbi.nlm.nih.gov/pubmed/18786987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01688-08
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