An Alphavirus Replicon-Based Human Metapneumovirus Vaccine Is Immunogenic and Protective in Mice and Cotton Rats

Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that causes upper and lower respiratory tract infections in infants, the elderly, and immunocompromised individuals worldwide. Here, we developed Venezuelan equine encephalitis virus replicon particles (VRPs) encoding hMPV fusion (F...

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Détails bibliographiques
Auteurs principaux: Mok, Hoyin, Tollefson, Sharon J., Podsiad, Amy B., Shepherd, Bryan E., Polosukhin, Vasiliy V., Johnston, Robert E., Williams, John V., Crowe, James E.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573258/
https://ncbi.nlm.nih.gov/pubmed/18786987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01688-08
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