An Alphavirus Replicon-Based Human Metapneumovirus Vaccine Is Immunogenic and Protective in Mice and Cotton Rats

Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that causes upper and lower respiratory tract infections in infants, the elderly, and immunocompromised individuals worldwide. Here, we developed Venezuelan equine encephalitis virus replicon particles (VRPs) encoding hMPV fusion (F...

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Main Authors: Mok, Hoyin, Tollefson, Sharon J., Podsiad, Amy B., Shepherd, Bryan E., Polosukhin, Vasiliy V., Johnston, Robert E., Williams, John V., Crowe, James E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2008
Ábhair:
Vaccines and Antiviral Agents
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573258/
https://ncbi.nlm.nih.gov/pubmed/18786987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01688-08
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