An Immunogenic and Protective Alphavirus Replicon Particle-Based Dengue Vaccine Overcomes Maternal Antibody Interference in Weanling Mice

A candidate pediatric dengue virus (DENV) vaccine based on nonpropagating Venezuelan equine encephalitis virus replicon particles (VRP) was tested for immunogenicity and protective efficacy in weanling mice in the presence and absence of potentially interfering maternal antibodies. A gene cassette e...

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Detalhes bibliográficos
Main Authors: White, Laura J., Parsons, Melissa M., Whitmore, Alan C., Williams, Brandon M., de Silva, Aravinda, Johnston, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045445/
https://ncbi.nlm.nih.gov/pubmed/17652394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00512-07
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