Lack of Interference with Immunogenicity of a Chimeric Alphavirus Replicon Particle-Based Influenza Vaccine by Preexisting Antivector Immunity

Antivector immunity has been recognized as a potential caveat of using virus-based vaccines. In the present study, an alphavirus-based replicon particle vaccine platform, which has demonstrated robust immunogenicity in animal models, was tested for effects of antivector immunity on immunogenicity ag...

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Detalhes bibliográficos
Main Authors: Uematsu, Yasushi, Vajdy, Michael, Lian, Ying, Perri, Silvia, Greer, Catherine E., Legg, Harold S., Galli, Grazia, Saletti, Giulietta, Otten, Gillis R., Rappuoli, Rino, Barnett, Susan W., Polo, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393363/
https://ncbi.nlm.nih.gov/pubmed/22623651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00031-12
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