Membrane translocation of diphtheria toxin carrying passenger protein domains.

For diphtheria toxin to be cytotoxic, the enzymatically active part (fragment A) must be translocated to the cytosol. We here demonstrate that additional proteins linked as N-terminal extensions can be translocated along with fragment A across the plasma membrane of toxin-sensitive cells. Thus, an e...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Madshus, I H, Olsnes, S, Stenmark, H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC257314/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1639497/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.60.8.3296-3302.1992
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