Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions.

Incubation of human keratinocytes with nanomolar concentrations of Staphylococcus aureus alpha-toxin leads to irreversible depletion of cellular ATP. The toxin forms hexamers in the target cell membranes, and rapid transmembrane flux of K+, Na+, and 86Rb+ is observed. Unexpectedly, pores formed in k...

Full description

Saved in:
Bibliographic Details
Main Authors: Walev, I, Martin, E, Jonas, D, Mohamadzadeh, M, Müller-Klieser, W, Kunz, L, Bhakdi, S
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC281271/
https://ncbi.nlm.nih.gov/pubmed/8225571
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items