Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions.

Incubation of human keratinocytes with nanomolar concentrations of Staphylococcus aureus alpha-toxin leads to irreversible depletion of cellular ATP. The toxin forms hexamers in the target cell membranes, and rapid transmembrane flux of K+, Na+, and 86Rb+ is observed. Unexpectedly, pores formed in k...

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Bibliographic Details

Published in:	Infect Immun
Main Authors:	Walev, I, Martin, E, Jonas, D, Mohamadzadeh, M, Müller-Klieser, W, Kunz, L, Bhakdi, S
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1993
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281271/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8225571/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.61.12.4972-4979.1993
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