Transmembrane β-barrel of staphylococcal α-toxin forms in sensitive but not in resistant cells

Staphylococcal α-toxin is a 293-residue, single-chain polypeptide that spontaneously assembles into a heptameric pore in target cell membranes. To identify the pore-forming domain, substitution mutants have been produced in which single cysteine residues were introduced throughout the toxin molecule...

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Main Authors: Valeva, Angela, Walev, Iwan, Pinkernell, Matthias, Walker, Barbara, Bayley, Hagan, Palmer, Michael, Bhakdi, Sucharit
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences of the USA 1997
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC23553/
https://ncbi.nlm.nih.gov/pubmed/9326657
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