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COMBINING THE INFLUENCE OF TWO LOW O(2)-AFFINITY INDUCING CHEMICAL MODIFICATIONS OF THE CENTRAL CAVITY OF HEMOGLOBIN
HexaPEGylated Hb, a non-hypertensive Hb, exhibits high O(2)-affinity which makes it difficult to deliver desired levels of oxygen to tissue. PEGylation of very low O(2)-affinity Hbs is now contemplated as the strategy to generate PEGylated Hbs with intermediate levels of O(2)-affinity. Towards this...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2572862/ https://ncbi.nlm.nih.gov/pubmed/17381072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0621462 |
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