Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate

Our recent studies on PEG–Hb [poly(ethylene glycol)–Hb] conjugates generated by thiolation-mediated maleimide-chemistry based PEGylation demonstrated that the vasoactivity of the PEG–Hb conjugates is a function of the configuration of the PEG chains on the surface of the protein and is independent o...

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Detalhes bibliográficos
Main Authors: Hu, Tao, Prabhakaran, Muthuchidambaram, Acharya, Seetharama A., Manjula, Belur N.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316295/
https://ncbi.nlm.nih.gov/pubmed/16111474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050663
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