PEGYLATION OF αα-Hb USING SUCCINIMIDYL PROPIONIC ACID PEG 5K: Conjugation Chemistry and PEG Shell of PEG αα-Hbs Dictate Respectively their Oxygen Affinity and Resuscitation Fluid Properties

PEGylation of intramolecularly crosslinked Hb has been studied here to overcome the limitation of dissociation of Hb tetramers. New hexa and deca PEGylated low oxygen affi nity PEG-αα-Hbs have been generated. Infl uence of PEG conjugation chemistry and the PEG shell structure on the functional prope...

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Main Authors: Meng, Fantao, Tsai, Amy G., Intaglietta, Marcos, Acharya, Seetharama A.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167218/
https://ncbi.nlm.nih.gov/pubmed/24597567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21691401.2014.885443
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