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Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

Self-templating amyloid forms of Sup35 constitute the yeast prion [PSI(+)]. How the protein-remodelling factor, Hsp104, collaborates with other chaperones to regulate [PSI(+)] inheritance remains poorly delineated. Here, we report how the Ssa and Ssb components of the Hsp70 chaperone system directly...

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Detalhes bibliográficos
Main Authors: Shorter, James, Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572177/
https://ncbi.nlm.nih.gov/pubmed/18833196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.194
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