Variant‐specific and reciprocal Hsp40 functions in Hsp104‐mediated prion elimination

The amyloid‐based prions of Saccharomyces cerevisiae are heritable aggregates of misfolded proteins, passed to daughter cells following fragmentation by molecular chaperones including the J‐protein Sis1, Hsp70 and Hsp104. Overexpression of Hsp104 efficiently cures cell populations of the prion [PSI...

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Bibliographic Details
Published in:Mol Microbiol
Main Authors: Astor, Michael T., Kamiya, Erina, Sporn, Zachary A., Berger, Scott E., Hines, Justin K.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099457/
https://ncbi.nlm.nih.gov/pubmed/29633387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13966
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