Characterization of Functional Heme Domains from Soluble Guanylate Cyclase

Soluble guanylate cyclase (sGC) is a heterodimeric, nitric oxide (NO)-sensing hemoprotein composed of two subunits, α1 and β1. NO binds to the heme cofactor in the β1 subunit, forming a 5-coordinate NO complex that activates the enzyme several hundred-fold. In this report the heme domain has been lo...

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Bibliografiske detaljer
Main Authors: Karow, David S., Pan, Duohai, Davis, Joseph H., Behrends, Sönke, Mathies, Richard A., Marletta, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572136/
https://ncbi.nlm.nih.gov/pubmed/16331987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051601b
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