Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3′-end maturation

In eukaryotes, the process of messenger RNA 3′-end formation involves endonucleolytic cleavage of the transcript followed by synthesis of the poly(A) tail. The complex machinery involved in this maturation process contains two proteins of the metallo-β-lactamase (MBL) superfamily, the 73 and 100 kDa...

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Hlavní autoři: Kolev, Nikolay G, Yario, Therese A, Benson, Eleni, Steitz, Joan A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
Témata:
Scientific Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572124/
https://ncbi.nlm.nih.gov/pubmed/18688255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.146
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