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Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5′–3′ exonuclease

Metazoan replication-dependent histone pre-mRNAs are cleaved at the 3′ end by U7 snRNP, an RNA-guided endonuclease that contains U7 snRNA, seven proteins of the Sm ring, FLASH, and four polyadenylation factors: symplekin, CPSF73, CPSF100, and CstF64. A fully recombinant U7 snRNP was recently reconst...

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Bibliografische gegevens
Gepubliceerd in:RNA
Hoofdauteurs: Yang, Xiao-cui, Sun, Yadong, Aik, Wei Shen, Marzluff, William F., Tong, Liang, Dominski, Zbigniew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7491329/
https://ncbi.nlm.nih.gov/pubmed/32554553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.076273.120
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