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Evidence that polyadenylation factor CPSF-73 is the mRNA 3′ processing endonuclease

Generation of the polyadenylated 3′ end of an mRNA requires an endonucleolytic cleavage followed by synthesis of the poly(A) tail. Despite the seeming simplicity of the reaction, more than a dozen polypeptides are required, and nearly all appear to be necessary for the cleavage reaction. Because of...

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Detalhes bibliográficos
Main Authors: RYAN, KEVIN, CALVO, OLGA, MANLEY, JAMES L.
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2004 by RNA Society 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370546/
https://ncbi.nlm.nih.gov/pubmed/15037765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5214404
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