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Inhibition and modulation of γ-secretase for Alzheimer’s disease

The 4-kDa amyloid β-peptide (Aβ) is strongly implicated the pathogenesis of Alzheimer’s disease (AD), and this peptide is cut out of the amyloid β-protein precursor (APP) by the sequential action of β- and γ-secretases. γ-Secretase is a membrane-embedded protease complex that cleaves the transmembra...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: Wolfe, Michael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572079/
https://ncbi.nlm.nih.gov/pubmed/18625450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nurt.2008.05.010
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