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Inhibition and modulation of γ-secretase for Alzheimer’s disease
The 4-kDa amyloid β-peptide (Aβ) is strongly implicated the pathogenesis of Alzheimer’s disease (AD), and this peptide is cut out of the amyloid β-protein precursor (APP) by the sequential action of β- and γ-secretases. γ-Secretase is a membrane-embedded protease complex that cleaves the transmembra...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Springer-Verlag
2008
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2572079/ https://ncbi.nlm.nih.gov/pubmed/18625450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nurt.2008.05.010 |
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