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Dysfunctional γ-secretase in familial Alzheimer’s disease
Genetics strongly implicate the amyloid β-peptide (Aβ) in the pathogenesis of Alzheimer’s disease. Dominant missense mutation in the presenilins and the amyloid precursor protein (APP) cause early-onset familial Alzheimer’s disease (FAD). As presenilin is the catalytic component of the γ-secretase p...
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| Publicado no: | Neurochem Res |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6592691/ https://ncbi.nlm.nih.gov/pubmed/29619615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-018-2511-1 |
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