Methylation of CIITA promoter IV causes loss of HLA-II inducibility by IFN-γ in promyelocytic cells

The human promyelocytic cell line THP-1 expresses high level of HLA class II (HLA-II) molecules after IFN-γ treatment. Here, we report a variant of THP-1 that does not express HLA-II after IFN-γ. The variant's HLA-II phenotype is constant over time in culture and it is not related to a defectiv...

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Main Authors: De Lerma Barbaro, Andrea, De Ambrosis, Alessandro, Banelli, Barbara, Pira, Giuseppina Li, Aresu, Ottavia, Romani, Massimo, Ferrini, Silvano, Accolla, Roberto S.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
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Original Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572003/
https://ncbi.nlm.nih.gov/pubmed/18829986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxn103
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