Regulation of Postsynaptic RapGAP SPAR by Polo-like Kinase 2 and the SCF(β-TRCP) Ubiquitin Ligase in Hippocampal Neurons

The ubiquitin-proteasome pathway (UPP) regulates synaptic function, but little is known about specific UPP targets and mechanisms in mammalian synapses. We report here that the SCF(β-TRCP) complex, a multisubunit E3 ubiquitin ligase, targets the postsynaptic spine-associated Rap GTPase activating pr...

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Detalhes bibliográficos
Main Authors: Ang, Xiaolu L., Seeburg, Daniel P., Sheng, Morgan, Harper, J. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570879/
https://ncbi.nlm.nih.gov/pubmed/18723513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802475200
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