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Polar or Apolar—The Role of Polarity for Urea-Induced Protein Denaturation

Urea-induced protein denaturation is widely used to study protein folding and stability; however, the molecular mechanism and driving forces of this process are not yet fully understood. In particular, it is unclear whether either hydrophobic or polar interactions between urea molecules and residues...

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Bibliographic Details
Main Authors: Stumpe, Martin C., Grubmüller, Helmut
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570617/
https://ncbi.nlm.nih.gov/pubmed/19008937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000221
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