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(±)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-ene Carboxylic Acid. A Potent GABA Aminotransferase Inactivator that Irreversibly Inhibits through an Elimination-Aromatization Pathway

Inhibition of γ-aminobutyric acid aminotransferase (GABA-AT) raises the concentration of GABA, an inhibitory neurotransmitter in human brain, which could have therapeutic applications for a variety of neurological diseases including epilepsy. Based on studies of several previously synthesized confor...

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Autori principali: Wang, Zhiyong, Yuan, Hai, Nikolic, Dejan, Van Breemen, Richard B., Silverman, Richard B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570588/
https://ncbi.nlm.nih.gov/pubmed/17128990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061592m
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