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Structural Modifications of (1S,3S)-3-Amino-4-Difluoromethylenecyclopentanecarboxylic Acid, a Potent Irreversible Inhibitor of GABA Aminotransferase
Low brain levels of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) leads to convulsions. Inhibition of GABA aminotransferase increases the concentration of GABA and can terminate the convulsions. Earlier we reported the synthesis of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxyl...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1853296/ https://ncbi.nlm.nih.gov/pubmed/17267220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.12.119 |
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