The Enantiomers of 4-Amino-3-fluorobutanoic Acid as Substrates for γ-Aminobutyric Acid Aminotransferase. Conformational Probes for GABA Binding

γ-Aminobutyric acid aminotransferase (GABA-AT), a pyridoxal 5’-phosphate dependent enzyme, catalyzes the degradation of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) to succinic semialdehyde with concomitant conversion of pyridoxal 5’-phosphate (PLP) to pyridoxamine 5’-phosphate (PMP)....

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Bibliographic Details
Main Authors: Clift, Michael, Ji, Haitao, Deniau, Gildas P., O’Hagan, David, Silverman, Richard B.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570590/
https://ncbi.nlm.nih.gov/pubmed/17988152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701249q
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