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Fluorinated Conformationally-Restricted γ-Aminobutyric Acid Aminotransferase Inhibitors

Based on the structures of several potent inhibitor molecules for γ-aminobutryric acid aminotransferase (GABA-AT) that were previously reported, six modified fluorine-containing conformationally-restricted analogues were designed, synthesized, and tested as GABA-AT inhibitors. The syntheses of all s...

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Detalhes bibliográficos
Main Authors: Lu, Hejun, Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577068/
https://ncbi.nlm.nih.gov/pubmed/17149870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0608715
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