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Substrate Specificity of γ-Secretase and Other Intramembrane Proteases
γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the precise factors regulating substrate identification is important because modulation of this biochemical degradative process...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2569971/ https://ncbi.nlm.nih.gov/pubmed/18239854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-008-7462-2 |
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